About

Costantine Daher, PhD

Dr. Costantine Daher was appointed as Interim Dean of the Alice Ramez Chagoury School of Nursing in September 2019 . Dr. Daher joined LAU in 1991 as an instructor and after earning his PhD degree in 1998 was promoted to Assistant Professor. Dr. Daher was also the interim Dean of the LAU School of Arts and Sciences.

Education

Scholarly Interests

Dr. Daher received his B.S. in biology and M.S in physiology from the American University of Beirut in 1986 and 1988, respectively. He joined LAU as an instructor of biology in 1991 and became Assistant Professor in 1998, after earning his Ph.D. in biomedical sciences from the University of Surrey in England, then Associate Professor in 2005. He served as chair of LAU’s Department of Natural Sciences between 2005 and 2014 and was also appointed Assistant Dean of the School of Arts and Sciences between September 2014 and August 2018.

His research mostly focuses on natural products as sources of therapeutic agents that could be used in the treatment of cancer, lipemia, glycemia and inflammation. He has published around 36 articles in various peer-reviewed international journals.

Selected Publications

  1. Andree Elias, Wassim N. Shebaby, Bilal Nehme, Wissam Faour, Bassem Bassil, Joelle Hakim, Rita Iskandar, Nahia Dib-Jalbout, Mohamad Mroueh, Costantine F. Daher, Robin I Taleb (2019). In vitro and in vivo evaluation of the anticancer and anti-inflammatory activities of 2-himachalen-7-ol isolated from Cedrus libaniScientific Reports Sci Rep. 9(1):12855. doi: 10.1038/s41598-019-49374-9.
  2.  Stephanie Mehanna, Najwa Mansour, Hassib Audi, Kikki Bodman-Smith, Mohamad A. Mroueh, Robin I. Taleb, Costantine F. Daher, and Rony S. Khnayzer (2019). Enhanced cellular uptake and photochemotherapeutic potential of a lipophilic strained Ru(II) polypyridyl complex”. RSC Advances 9(30):17254-17265.
  3.  Hamid E. Daaboul, Carole Dagher, Robin I. Taleb, Kikki Bodman-Smith, Wassim N. Shebaby, Mirvat El-Sibai, Mohamad A. Mroueh, Costantine F. Daher (2019). β-2-himachalen-6-ol inhibits 4T1 cells-induced metastatic triple negative breast carcinoma in murine model. Chemico-Biological Interactions, 309:108703. doi: 10.1016/j.cbi.2019.06.016.
  4.  Zein N., Abdallah M., Daher C., Mroueh M., Stephan J., Bahous S.A., Faour W. (2019). Ghrelin Modulates Intracellular Signaling Pathways That are Critical for Podocyte Survival. Cell Biochem Funct. Apr 24. doi: 10.1002/cbf.3397. [Epub ahead of print]
  5.  Mansour, N.; Mehanna, S.; Taleb, R. I.; Mroueh, M.; Bodman‐Smith, K.; El-Sibai, M.; Daher, C. F.; Khnayzer, R. S. (2018). Photoactivatable Ru(II) complex bearing 2,9-diphenyl-1,10- phenanthroline: unusual photochemistry and significant potency on cisplatin-resistant cell lines. European Journal Inorganic Chemistry, 22, 2524-2532.
  6. Hamid E. Daaboul, Carole Dagher, Robin I. Taleb, Kikki Bodman-Smith, Wassim N. Shebaby, Mirvat El-Sibai, Mohamad A. Mroueh, Costantine F. Daher (2018). The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis. Biomedicine & Pharmacotherapy 103:443-452.
  7. Hamid Daaboul, Costantine F. Daher, Kikki Bodman-smith, Robin Taleb, Wassim Shebaby, Carole Dagher, Joelle Boulos, Mohamad Mroueh (2017). Antitumor activity of β-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways. Chemico-Biological Interactions, 275: 162-170.
  8. Hamid E Daaboul, Costantine F Daher, Robin I Taleb, Joelle C. Boulos, Kikki Bodman-Smith, Petra Boukamp, Wassim N Shebaby, Carol Dagher, Mirvat El-Sibai, and Mohamad A Mroueh (2017). β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivoJournal of Pharmacy and Pharmacology 69(11):1552-1564. 
  9. Wassim N Shebaby, Mohamad A Mroueh, Petra Boukamp, Robin I Taleb RI, Kikki Bodman-Smith, Mirvat El-Sibai and Costantine F Daher (2017). Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer. Under review in BMC Complementary and Alternative Medicine, 17(1):149. doi: 10.1186/s12906-017-166.